Central regulation of blood pressure by the mineralocorticoid receptor

Vascular mineralocorticoid receptor and blood pressure regulation.

The mineralocorticoid receptor (MR) is a major regulator of blood pressure by modulating sodium balance and blood volume in the distal nephron. The discovery of MR expression in both endothelial and vascular smooth muscle cells a decade ago raised questions about its role in the vascular wall and its involvement in blood pressure regulation. In vitro and in vivo pharmacological studies have sho...

How do central mineralocorticoid receptors modulate blood pressure?

TIME WAS, and sometimes still is for those with a nephrocentric world view, when the way aldosterone elevated blood pressure was simple: renal sodium and water retention, increased blood volume causing increased cardiac output, reflex vasoconstriction, and normalization of cardiac output. We now know that aldosterone has direct vasoconstrictor effects on the vascular wall and, thanks in no smal...

Central regulation of arterial blood pressure.

T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.

RATIONALE Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not been elucidated. OBJECTIVE We aim to determine the role of T...

Peripheral and Central Effects of Melatonin on Blood Pressure Regulation

The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), shows potent receptor-dependent and -independent actions, which participate in blood pressure regulation. The antihypertensive effect of melatonin was demonstrated in experimental and clinical hypertension. Receptor-dependent effects are mediated predominantly through MT1 and MT2 G-protein coupled receptors. The pleiotropic receptor-...